On the contrary, a recent paper showed that activation of mTORC1 pathway may help suppress the drug resistance of T-ALL in hypoxic niches [55]. It is intriguing that while AMPK functions as an antagonist of mTOR [56]; both AMPK and mTOR signaling pathways were inhibited in NALM-6/HDR cells, which is consistent with the findings in CEM-C7/HDR [6]. Here, MTOR is linked to acute lymphoblastic leukemia.