Furthermore,, PPARβ inhibitor (DG172 dihydrochloride, 1 mg/kg) increased IL-1β level, promoted myocardial damage, and suppressed PPARβ protein expression in mice of myocardial ischemia-reperfusion by KLF16 human recombinant protein (Figures 9(a-d)). This evidence concerns the gene IL1B and myocardial ischemia.