Notably, PPARβ agonist (GW0742, 1 μM) reduced IL-1β level, presented myocardial damage, and induced PPARβ protein expression in vitro model of myocardial ischemia-reperfusion by down-regulation of KLF16 (Figure 9(i-k)). The gene discussed is IL1B; the disease is myocardial ischemia.