Through up-regulation of KLF16, PPARβ inhibitor (DG172 dihydrochloride, 5 nM) increased IL-1β level, promoted myocardial damage, and suppressed PPARβ protein expression in mice of myocardial ischemia-reperfusion (Figure 9(l-n)). The gene discussed is KLF16; the disease is myocardial ischemia.