Interestingly, PPARβ inhibitor (DG172 dihydrochloride, 1 mg/kg) increased MDA level, and reduced SOD, GSH and GSH-PX levels in mice of myocardial ischemia-reperfusion by KLF16 human recombinant protein (Figure 10(a-d)). The gene discussed is KLF16; the disease is myocardial ischemia.