The role of Piezo1 on cell migration is controversial, as some reports show that inhibition of Piezo1 increases cell migration, such as in breast cancer and non-small cell lung carcinoma (Huang et al., 2019; Yu et al., 2021), whereas others show inhibition in cell migration, such as in gastric cancer and glioma cells (Chen et al., 2018; Zhang et al., 2018). Here, PIEZO1 is linked to breast cancer.