The adipocytokines such as tumor necrosis factor-alpha (TNF-α), leptin, adiponectin, resistin, and plasminogen activator 1 (PAI-1) released by the adipocytes control appetite, insulin sensitivity, and inflammation, which also take part in the pathogenesis of MAFLD and its progression to NASH [73,74,75,76]. The gene discussed is SERPINE1; the disease is metabolic dysfunction-associated steatohepatitis.