Thus, mutations in polycystin-1 (PKD1), polycystin-2 (PKD2), neutral alpha-glucosidase AB (GANAB, or PKD3), and the homologous subfamily DnaJB11 (DNAJB11 or PKD6) genes, are associated with ADPKD disease. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.