In addition to the presence of anti-DSG2 antibodies in human subjects with ARVC [11], reduction of the immunofluorescent signal for the desmosomal protein plakoglobin (PG) in endomyocardial biopsy (EMB) samples is another potential factor to help diagnose ARVC [17,18]. Here, DSG2 is linked to arrhythmogenic right ventricular cardiomyopathy.