It is well established that the CXCL5/CXCR2 and IL-8/CXCR1/CXCR2 axes contribute to carcinogenesis by promoting tumor cell proliferation, migration, and invasion, and the EMT process of many tumor cells, including NSCLC [50,51,52,53], hepatocarcinoma cells [54], and papillary thyroid carcinoma cells [55]. The gene discussed is CXCL5; the disease is non-small cell lung carcinoma.