CXCL8 and cancer: CTX also inhibits chemokines that bind to CXCR1 and CXCR2 receptors such as CXCL5, CXCL1/2/3, CXCL1a, CXCL6, and CXCL8 (IL-8) that are involved in cancer angiogenesis and metastasis (Figure 5C).