We examined the effect of LMW-AV on the mRNA expression of chemokines and cytokines associated with the pathogenesis of AD, including eotaxin, interleukin (IL)-4, macrophage-derived chemokine (MDC), regulated upon activation, normal T cell expressed and presumably secreted (RANTES), thymic stromal lymphopoietin (TSLP), and thymus and activation regulated chemokine (TARC), in dorsal skin lesions of AD-induced mice. This evidence concerns the gene CCL5 and Alzheimer disease.