IGHE and acute basophilic leukemia: MCCC 1A11233 (CDMW), CDMW-3, CDMW-5, and CDMW-15, demonstrated antiallergic activity due to the block of mast-cell-dependent passive cutaneous anaphylaxis in IgE-sensitized mice and to the decrease of degranulation and histamine release in immunoglobulin E (IgE)-mediated rat basophilic leukemia (RBL)-2H3 cells [142].