Inside the nucleus, the GC/GR complex regulates up to 20% of genes expressed by immune cells by trans-repressing inflammatory genes and stimulating the transcription of anti-inflammatory genes, leading to the reduced activation, recruitment, and survival of inflammatory and epithelial cells [29,30,31]; it also regulates mRNA stability [32] and the immunomodulatory function of smooth muscle cells and airway remodeling in asthma [33]. Here, NR3C1 is linked to asthma.