Gysemans and colleagues found that loss of signal transducer and activator of transcript-1 (STAT-1), a transcription factor activated by both IFNγ and IFNα, prevents β-cell death in response to IFNγ and IL-1β in vitro, and protected from STZ-induced hyperglycemia in vivo. Here, STAT1 is linked to Hyperglycemia.