Tersey and colleagues found that loss of 12-lipoxygenase (12-LO), an enzyme involved in the oxidation of arachidonic acid to proinflammatory intermediates, increases the expression of islet antioxidant enzymes Sod1 and Gpx1, and protects against hyperglycemia in response to a high fat diet [226]. The gene discussed is ALOX12; the disease is Hyperglycemia.