The aim of this study was to determine the pattern of adiponectin, OCN, irisin, FGF-21, and MCP-1 according to the body size phenotype in middle-aged women, to identify the differences between groups and to evaluate the association of these cytokines with BMI, visceral adipose tissue (VAT), insulin and the homeostasis model assessment of insulin resistance (HOMA-IR). The gene discussed is FGF21; the disease is Insulin resistance.