INS and obesity due to melanocortin 4 receptor deficiency: On the other hand, MHO is characterized by a 2.6-fold lower visceral fat deposition, a lower liver fat mass, a higher leg fat content, greater insulin sensitivity, normal inflammation markers, and a preserved adipose tissue function when compared to individuals with MUO [6]; however, MHO is said to be a transient state [6,13] and despite what might be expected, individuals with this phenotype also have a higher risk of developing major vascular events, which shows that obesity remains a major risk factor for cardiovascular disease which is independent of other metabolic factors [13].