In our study, we corroborated that the VAT was higher in women with obesity; however, in normal weight women, those with a metabolically unhealthy phenotype had a higher amount of VAT than metabolically healthy women, and VAT showed an association with some cytokines, such as adiponectin, irisin, and MCP-1. Here, FNDC5 is linked to obesity due to melanocortin 4 receptor deficiency.