SOST and cardiovascular disorder: For the first sclerostin allele set (rs9899889, rs1107748, rs66838809), which is associated with reduced expression of sclerostin and increased BMD, no association with cardiovascular disease was identified using the data of two population-based studies of cardiovascular risk (CARDIoGRAMplusC4D and MEGASTROKE) encompassing over 1 million participants.