Recently published data suggest that uremic vessels can have adverse effects on bone [27]: When a piece of uremic aorta from a rat with CKD was transplanted into a kidney-healthy animal, the bone mineral density of the (otherwise healthy) recipient animal decreased, mainly through the impaired mineralization of bone, with marked increases in osteopontin and ANKH (progressive ankylosis protein homolog) [27], both inhibitors of mineralization. This evidence concerns the gene ANKH and chronic kidney disease.