G6PC1 and nonpapillary renal cell carcinoma: First, the genes controlling renal gluconeogenesis (G6PC, PCK1, and FBP1) were found to be the most under expressed metabolic gene set based on analysis of RNA-sequencing data of ccRCC [43] and secondly, overexpression of gluconeogenic enzyme FBP1 significantly inhibited 2D culture and xenograft tumor growth [43].