PGR and cancer: There are five main molecular subtypes of breast cancer that are associated with the expression of three receptors in tumor cells, namely estrogen (ER), progesterone (PR), and human epidermal growth factor receptor-2 (HER2); Luminal A cancers largely correspond to ER or PR positive, HER2 negative, and low histological grade/proliferation rate, while Luminal B tumors display relatively lower levels of ER or PR expression, and either exhibit HER2 amplification, high histological grade/high proliferation, or both.