In contrast in the large meta-analysis by Li et al. [69] which included 68 RCTs (total of 4601 subjects) they found that marine-derived n-3 PUFA (EPA, DHA, fish oil) significantly decreased CRP, TNF-α and IL-6 in healthy (particularly older subjects) and in patients with chronic non-autoimmune disease. This evidence concerns the gene CRP and autoimmune disease.