However, further insight into the role of HIF-1α in GvHD is warranted since another animal study demonstrated a contrasting effect of HIF-1α, i.e., its stabilization via the prolyl hydroxylase inhibitor, dimethyl oxalyl glycine (DMOG), led to improved survival in the same MHC mismatch model (C57BL/6-> BALB/c) [94]. The gene discussed is HIF1A; the disease is graft versus host disease.