The performance of NSE regarding overall mortality and neurological outcome was measured on day 3 after cardiac arrest using a threshold of 60 ng/mL, and the specificity was higher (94.6% and 95.2% versus 80.2% and 83.9% for primary and secondary endpoint) at the cost of a lower sensitivity (53.5% and 58.1% at 60 ng/mL versus 70.2% and 75.2% at 33 ng/mL) (Supplementary Table S3). Here, ENO2 is linked to cardiac arrest.