FGF21 and obesity due to melanocortin 4 receptor deficiency: Since FGF21 is also well recognized for its anti-inflammatory properties in obesity related inflammation, Kang and colleagues, demonstrated that combination of FGF21 with adipose-derived mesenchymal stem cells (ASCs) considerably improved their anti-inflammatory and antifibrotic properties in an in vitro mouse model of thioacetamide-induced liver fibrosis.