KRAS and malignant colon neoplasm: To this end, we compared the metabolic profiles of the parental KRASG13D/+ (parental line isolated from a colorectal cancer patient in which glycine (G) 13 is mutated to aspartate (D)) and its isogenic derivative cell lines KRAS+/– and KRASG13D/– in human colon cancer cells (HCT116).