KCNA5 and rheumatoid arthritis: For example, targeting the Kv8.1 subunit ought to affect only brain tissue with minimal effect on other tissues [34], while selective targeting Kv1.3 is promising in the treatment of autoimmune disorders since it is one of the major Kv channels (along with Kv1.5 [35]) expressed in leukocytes and was shown to be associated with rheumatoid arthritis and type 1 diabetes mellitus [28].