In 2015, Bray et al. were able to show that the formation of tumors and vascular-like structures occurs in cultures containing tumor cells mesenchymal stromal cells, and HUVEC endothelial cells in a modified soft (star- PEG) hydrogel and in Matrigel, when supplemented by addition of 5 μg/mL of each VEGF, FGF-2 and SDF 1 [22]. Here, VEGFA is linked to neoplasm.