However, it should be considered that a decrease in total MMP-2 levels does not equate to decreased MMP-2 activity, and the results presented here do not rule out a role for altered MMP-2 activity in the aortic wall—perhaps modulated by GLP-1 signaling—in the reduced prevalence of TAAs in T2D. This evidence concerns the gene MMP2 and type 2 diabetes mellitus.