LGALS3 and amyotrophic lateral sclerosis: Elevated serum and cerebrospinal fluid levels of Gal-3 were found in both Alzheimer’s and Amyotrophic Lateral Sclerosis (ALS) patients, with a positive correlation with the MMSE (Mini-Mental State Examination) score, plasma Gal-3 being able to predict the neuropsychological decline [89,90].