A tumor microenvironment (TME) consists of tumor cells; tumor stromal cells including stromal fibroblasts, endothelial cells, and microglia; immune cells such as macrophages and lymphocytes; and non-cellular components of the extracellular matrix such as collagen, fibronectin, hyaluronic acid, and laminin [1,2,3,4,5,6]. Here, FN1 is linked to neoplasm.