Hyperglycemia results from the combination of different pathophysiological anomalies ranging from resistance to insulin action (both liver and muscle), by its inadequate secretion, by excessive or inappropriate glucagon secretion, by reduced incretin effect, by increased lipolysis, due to increased renal glucose reabsorption and dysfunction of brain neurotransmitters [5,51,53,54]. The gene discussed is INS; the disease is Hyperglycemia.