CDH2 and neoplasm: However, we found that fisetin could remarkably elevate the content of epithelial marker E-cadherin and dampened the content of interstitial markers N-cadherin along with a-SMA (Figure 6A–6D), which resulted in the decrease of extracellular matrix (ECM) secreted by stromal tumor cells, for instance type I and III collagen (Figure 6A, 6F, 6G).