In addition, we have also observed that the expressions of metalloprotease system linked proteins, consisting of MMP-2 along with MMP-9, which have remarkable modulatory effects on tumor cell invasion and migration, are also inhibited by fisetin (Figure 5E), which proved again fisetin dampened infiltration, as well as migration in pancreatic cancer cells. Here, MMP9 is linked to familial pancreatic carcinoma.