Figure 8A, 8C illustrates that a remarkable difference in tumor volume was seen as per the tumor image after 30 days. The mean tumor volume along with the weight were remarkably different between the study groups (Figure 8B, 8D). Western blotting illustrated that the expressions of PI3K, p-AKT, as well as p-mTOR proteins were downregulated obviously in fisetin treatment group (Figure 8E, 8F, 8H). These data exhibit that fisetin dampens the pancreatic tumor growth in vivo. Here, AKT1 is linked to neoplasm.