Perturbing CALM experimentally alters the trafficking of proteins associated with driving Alzheimer’s Disease pathogenesis and it will be of interest to determine whether some of those effects are due to the function of CALM as an adaptor for ubiquitinated proteins (Harel et al., 2011; Kanatsu et al., 2016; Kanatsu et al., 2014; Moreau et al., 2014; Wu et al., 2009). The gene discussed is PICALM; the disease is early-onset autosomal dominant Alzheimer disease.