Closer to the context of COVID-19 pathophysiology, critical roles of HSA have been suggested as it acts as an anti-inflammatory and antioxidant protein (Inoue et al., 2018), anticoagulant agent (Doweiko and Nompleggi, 1991; Ronit et al., 2020), inhibitor of oxidative stress-mediated clotting and platelet activation (Basili et al., 2019; Tian et al., 2020), drug-dependent allosteric carrier and regulator (Fanali et al., 2012), and a potent heme scavenger that may also exhibit globin-like reactivity (Ascenzi et al., 2015). This evidence concerns the gene ALB and COVID-19.