In view of the distribution of the NgR+cells around the periphery of the plaques (VanGuilder & Sonntag, 2013; Zhu & Guo, 2007) and the colocalization of NgR and microglia was detected in hippocampus and cerebral cortex in the 8‐month‐old AD transgenic mice (Fang & Yao, 2016), we dissected the role of NgR expressed on the microglia in AD transgenic model mice. This evidence concerns the gene RTN4R and Alzheimer disease.