To investigate whether the reduction of amyloid plaque deposition and Aβ levels induced by NgR knockdown is associated with improved memory performance, we assessed spatial memory in 14‐month‐old WT+LV‐control, WT+LV‐shNgR, APP/PS1+LV‐control, and APP/PS1+LV‐shNgR mice using the novel object recognition (NOR) test, which is a memory task that relies on the innate preference of mice for a novel rather than familiar object. This evidence concerns the gene APP and amyloidosis.