In contrast, our data of TE4 cells (a miR205HG‐low expressed ESCC cell lines) with miR205HG overexpression revealed that the ectopic miR205HG enhances MYH11 and SPINK5 expression but suppressed BGN, COL10A1, COL5A1, MMP1, MMP3, and IL1B expression (Fig. 2F,G). This evidence concerns the gene MMP1 and esophageal squamous cell carcinoma.