APOE and atherosclerosis: In this research, we discovered that the levels of lncRNA H19 expression were considerably upregulated in mouse blood and aorta with atherosclerosis and ox-LDL-treated THP-1 macrophages, and the lncRNA H19 overexpression increased the atherosclerotic lesion size, promoted plaque lipid disposition and reduced collagen content in apoE−/− mice, whereas a reverse impact was observed in response to knockdown of lncRNA H19.