⁃ Overexpression of SPHK1 increased the proliferation and migration of NSCLC via activation of PI3K/AKT/NF-κB and increased expression of Bcl-xl, c-IAP1, c-IAP2, TRAF1, Bcl-2, matrix metallopeptidase 2 and cyclin D1. The gene discussed is MMP2; the disease is non-small cell lung carcinoma.