The frequency of γδ T cells co-expressing PD-1, TIM-3, and CD39 together with TIGIT was significantly higher in samples from AML and MM in comparison to HDs (AML vs. HD: p = 0.006, p = 0.001, p = 0.08 and MM vs. HD: p = 0.004, p = 0.004, p = 0.017; Figure 5A). This evidence concerns the gene TIGIT and acute myeloid leukemia.