CYCS and Sepsis: In addition, damaged mitochondria generate a significant amount of danger associated molecular patterns (DAMPs) during sepsis (Zhang et al., 2010), including mitochondrial ROS (mtROS), mitochondrial DNA (mtDNA) fragments and cytochrome C. These molecules participate in inciting inflammation or directly injure myocytes, resulting in myocardial dysfunction (Zang et al., 2012).