In addition, although CAV1, SMAD7, BMP2, EDN1, and CXCL12 were not significantly different in the prognostic analysis in our study, they also play important roles in the occurrence and development of lung cancer (Katsura et al., 2018; Yan et al., 2019; Huang et al., 2020; Pulido et al., 2020; Tong et al., 2020). This evidence concerns the gene SMAD7 and lung cancer.