Among them, cysteine dioxygenase 1 (CDO1), toll-like receptor 4 (TLR4), and dual oxidase 1 (DUOX1) were downregulated in tumors and played a protective role, while Fanconi anemia complementation group D2 (FANCD2) and others were with high expression in tumors and were risk factors for prognosis. The gene discussed is DUOX1; the disease is Fanconi anemia.