This study systematically analyzed the differential expressions of PRGs between the HCC and normal samples; explored the clinical prognostic value of these genes through Cox expression analysis; established an independent prognostic model based on PRGs; investigated the relationship between the pyroptosis and tumor immune microenvironments; validated the mRNA expressions of PRGs in vivo and in vitro; and evaluated the drug sensitivity of these prognostic factors. The gene discussed is GART; the disease is hepatocellular carcinoma.