We found that 13 PRGs (CHMP2A, GPX4, HMGB1, DHX9, BAX, TP53, BAK1, CASP3, DFNA5, CASP8, APIP, CHMP2B, and CYCS) were upregulated in HCC, while 22 genes (CHMP6, TNF, CHMP7, CASP5, NLRP3, IL1A, ZBP1, CHMP4A, PYCARD, CASP4, CASP1, GZMA, IL18, GZMB, AIM2, IL1B, IL6, NLRP1, NOD1, IRF2, PRKACA, and CASP9) were downregulated compared with normal liver. Here, BAK1 is linked to hepatocellular carcinoma.