Among them, we identified 35 DEGs, including 13 upregulated genes (CHMP2A, GPX4, HMGB1, DHX9, BAX, TP53, BAK1, CASP3, DFNA5, CASP8, APIP, CHMP2B, and CYCS) and 22 downregulated genes (CHMP6, TNF, CHMP7, CASP5, NLRP3, IL1A, ZBP1, CHMP4A, PYCARD, CASP4, CASP1, GZMA, IL18, GZMB, AIM2, IL1B, IL6, NLRP1, NOD1, IRF2, PRKACA, and CASP9) in HCC tissue. Here, CASP8 is linked to hepatocellular carcinoma.