HIF1A and neoplasm: A growing number of HIF1α-inhibitory agents, including both chemical inhibitors (topotecan, PX-478, YC-1, 2-ME2, BAY87-2243, and digoxin) and antisense oligonucleotides (EZN-2968) have shown encouraging antitumor activities in blocking tumor growth and metastasis in multiple preclinical models (Semenza, 2012).