Given the strong association of certain somatic mutations with PCa progression and metastasis, many candidate genes, such as AR (Androgen Receptor) CAG/CGN repeats, TMPRSS2-ERG (Transmembrane Protease, Serine 2- ETS related gene) fusion, LSAMP (Limbic System Associated Membrane Protein), APC (Adenomatous Polyposis Coli), ATM, BRCA2, KDM6A (Lysine Demethylase 6A), KMT2C (Lysine Methyltransferase 2C), KMT2D (Lysine Methyltransferase 2D), MED12 (Mediator Complex subunit 12), ZFHX3 (Zinc finger Homeobox 3), and ZMYM3 (Zinc Finger MYM-type Containing 3) have been identified. This evidence concerns the gene APC and posterior cortical atrophy.