Utilizing positional cloning with linkage analysis successfully linked hereditary prostate cancer gene 1 (HPC1) at 1q24-25, HPCX (Hereditary Prostate Cancer gene X) at Xq27-28, linkage at 8p22-23, HPC20 (Hereditary Prostate Cancer gene 20) at 20q13, HOXB13 (Homeobox B13) and others. The gene discussed is STX1A; the disease is prostate cancer, hereditary.