In 2012, the United States Preventive Services Task Force (USPSTF) issued concerns about the risk of possible untoward side effects due to unnecessary biopsies, overdiagnosis, and overtreatment of screen-detected, indolent tumors which led to a Grade D recommendation against blanket PSA-based screening for PCa (18). The gene discussed is KLK3; the disease is posterior cortical atrophy.