The spectrum of the overlap in patients of AIH and PBC may be immune-serologic overlap, e.g., positive ANA, ASMA, and raised IgG in conjunction with AMA and other associated autoantibodies, or a biochemical overlap of transaminases > 5 ULN in patients with PBC, or histologic overlap with lymphoplasmacytic infiltrate or interphase hepatitis in patients with bile duct lesions characteristics of PBC [26]. This evidence concerns the gene BTG3 and primary biliary cholangitis.