Methylation of cyclin-dependent kinase-2 (cdk2A), adenomatous polyposis coli (APC), Cadherin-13 (CDH13), p16 (also known as cyclin-dependent kinase inhibitor 2A, CDKN2A), and Ras association domain family protein1 isoform A (RASSF1A), for example, has been linked to recurrence after surgical resection of stage I NSCLC, regardless of histological background, gender, or smoking history [18]. The gene discussed is CDKN2A; the disease is non-small cell lung carcinoma.