In vitro experiments have demonstrated that its knockout can inhibit the migration of p-catenin from the cytoplasm to the nucleus, resulting in decreased expression of c-MYC and MMP-7, whereas overexpression of MALAT1 can activate the Wnt/p-catenin pathway and promote the invasion and metastasis of CRC (Ji et al., 2013). The gene discussed is MYC; the disease is colorectal carcinoma.