When the p value < 0.05, we obtained four ncRNAs that regulated the core prognosis gene (Table 3), including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) (associated with tumor cell proliferation and metastasis), colorectal neoplasia differentially expressed (CRNDE) (promotes colorectal cancer cell proliferation), FOXF1 adjacent noncoding developmental regulatory RNA (FENDRR) and taurine upregulated gene 1 (TUG1) (regulation of resistance to colorectal cancer methotrexate). The gene discussed is MALAT1; the disease is colorectal cancer.