HNF4A and malignant colon neoplasm: Luo et al. (2014) reported that quercetin may inhibit cell proliferation and induce apoptosis through the bcl-2 and c-myc genes. Park et al. (2005) found that quercetin could significantly inhibit the transcriptional activity of catenin/Tcf signals in SW480 colon cancer cells by reducing the protein levels of large-catenin and Tcf in the nucleus.