Twelve hub genes, ENO2, GRP, HIST1H2AC, HIST1H2AK, HIST1H4H, HIST4H4, HOXB4, HSPB1, MIFT, POMC, QRFP, and TNFAIP6, had weak value in predicting the survival of colorectal cancer with >0.5 AUCs (Fig. 10). Here, ENO2 is linked to colorectal cancer.