In mouse colorectal cancer cells, active phosphorylated CREB is elevated (Sampurno et al., 2013), and p300 can assist the phosphorylation of CREB and activate intestinal stem cell transcription factors, including Myb, that regulate the proliferation of intestinal epithelial cells (Ramaswamy et al., 2018). The gene discussed is EP300; the disease is colorectal cancer.