In the present study, SNP loci with a minor allele frequency (MAF) ≥5% in the functional region of the ULK1 and PIK3CA genes were selected, and the association between these two gene polymorphisms and susceptibility to MPA was explored in a group of patients with MPA and a healthy control group from the Guangxi Zhuang Autonomous Region in China. This evidence concerns the gene PIK3CA and microscopic polyangiitis.