BUB1 (budding uninhibited by benzimidazole 1) is a mitotic checkpoint protein that is overexpressed in various types of cancer, including breast cancer, gastric cancer, pancreatic cancer and so on (Han et al., 2015; Piao et al., 2019; Bai et al., 2019). This evidence concerns the gene BUB1 and familial pancreatic carcinoma.