GRID2 and essential thrombocythemia: A comprehensive translational study in a mouse model of ET, together with high-density cerebellar EEG and post-mortem material in ET patients, has shown evidence for a model where deficient climbing fibers-to-Purkinje cell synapses, related to a primary insufficiency of glutamate receptor delta 2 (GluRδ2) proteins, may lead to excessive cerebellar oscillations that drive ET [14].