The NOD2/CARD15 (nucleotide oligomerization domain 2/caspase recruitment domain 15) gene is responsible for the synthesis of proteins that activate the nuclear factor kappa B (NFκB), which has a role in apoptosis and innate immune response, and the susceptibility gene mutations of NOD2/CARD15 are the first to be associated with IBD [2]. This evidence concerns the gene NOD2 and inflammatory bowel disease.