Upregulated lncRNA H19 in tissues from IPF patients downregulates miR-140 and modulates TGF-β/Smad3 signaling, and further in vivo and in vitro experiments show that the knockdown of H19 diminishes pulmonary fibrosis (Wang et al., 2019). The gene discussed is TGFB1; the disease is idiopathic pulmonary fibrosis.