STAT6 and pulmonary fibrosis: Thus, inhibition of miR-142-5p and overexpression of miR-130a-3p suppress lung fibrosis through stimulation of the STAT6 pathway by targeting peroxisome proliferator-activated receptor γ (PPARγ, a STAT6 coordinator) and suppressor of cytokine signaling 1 (SOCS1, a STAT6 inhibitor), respectively, which facilitates macrophage activation and contribute to extensive tissue fibrosis.