MiR-199a-3p negatively regulates the NF-kB signaling pathway and IL-8 via its target inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ), which is implicated in the NF-κB pathway, and downregulation of miR-199a-3p contributes to pulmonary inflammation in the CF airways (Bardin et al., 2018). The gene discussed is IKBKB; the disease is cystic fibrosis.