AKT1 and cystic fibrosis: For example, the elevated expression of miR-155 in the CF lung epithelium leads to downregulation of SH-2 containing inositol 5′ polyphosphatase 1 (SHIP1), an inositol 5-phosphatase, and thereby induces IL-8 expression via regulation of phosphatidylinositol-3 kinase/protein kinase B (PI3K/Akt) signaling (Bhattacharyya et al., 2011).