ADAMTS1 and idiopathic pulmonary fibrosis: MiR-21 is upregulated in peripheral blood from IPF patients, and inhibition of miR-21 in rat models upregulates its target a disintegrin-like and metalloproteinase with thrombospondin type 1 motif (ADAMTS-1), which downregulates pulmonary collagen type 1 (Col1) and collagen type 3 (Col3) contents and reduces the progression of IPF (Liu et al., 2016).