IL5 and asthma: In a murine model of asthma, miR-221 and miR-485-5p regulate interleukin-5 (IL-5) by targeting sprouty-related protein with an EVH1 domain-2 (Spred-2), which negatively regulates the Ras/ERK pathway involved in a variety of cellular processes, including airway inflammation and hypersensitivity (Liu et al., 2012).