TTR and chronic kidney disease: The biomarkers that were most commonly associated with risk or early detection of CKD were genes and genetic variants on chromosomes 16 and 22 (Kao et al., 2008; Shlush et al., 2010; Igo et al., 2011; Liao et al., 2014; Taira et al., 2018; Morris et al., 2019), the CKD273 biomarker panel (consisting of proteins such as collagen fragments, uromodulin, α-1-antitrypsin, transthyretin and β-2-microglobulin) (Good et al., 2010; Siwy et al., 2014; Øvrehus et al., 2015; Lindhardt et al., 2017), and the metabolite PA (also known as pantothenate or vitamin B5) (Gonzalez-Calero et al., 2016).