Upregulation of IL8 helps to recruit neutrophils to the site of infection, which are involved in the reorganization of ECM and basement membrane (Singer and Sansonetti, 2004; de Oliveira et al., 2013; Jennings and Knaus, 2014), whereas IL6 increases endothelial permeability due to the reorganization of actin filaments (Maruo et al., 1992). This evidence concerns the gene CXCL8 and infection.