Though effects on the hippocampus are more commonly associated with Alzheimer's disease, considerable tau accumulation can be observed in the hippocampus in PSP; however, it was found to be independent and the tau accumulation in PSP is more pronounced in strategic regions related to the disease's progression such as the brainstem and basal ganglia (35). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.