On the other hand, a study by Soares al. based on increased hippocampal levels of AMPA and NMDA receptor subunits GluA1 and GLUN1 and decreased hippocampal glucocorticoid receptor levels, suggested that alteration of glutamatergic neurotransmission and abnormal glucocorticoid signaling in hippocampus is typical for prediabetes (25, 26). Here, NR3C1 is linked to prediabetes syndrome.